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KMID : 1161420180210070709
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Journal of Medicinal Food
2018 Volume.21 No. 7 p.709 ~ p.715
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Hepatoprotective Effect of Essential Oils from Hyptis crenata in Sepsis-Induced Liver Dysfunction
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Lima Glauber Cruz
de Abreu Gomes Vasconcelos Yuri
de Santana Souza Marilia Trindade
Oliveira Alan Santos
Bomfim Rangel Rodrigues
de Albuquerque Ricardo Luiz Cavalcanti Junior
Camargo Enilton Aparecido
Portella Viviane Gomes
Coelho-de-Souza Andrelina Noronha
Diniz Lucio Ricardo Leite
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Abstract
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No specific therapeutics are available for the treatment of sepsis-induced liver dysfunction, a clinical complication strongly associated with the high mortality rate of septic patients. This study investigated the effect of the essential oil of Hyptis crenata (EOHc), a lamiaceae plant used to treat liver disturbances in Brazilian folk medicine, on liver function during early sepsis. Sepsis was induced by the cecal ligation and puncture (CLP) model. Rats were divided into four groups: Sham, Sham+EOHc, CLP, and CLP+EOHc. EOHc (300?mg/kg) was orally administered 12 and 24?h after surgery. The animals were sacrificed for blood collection and liver tissue samples 48?h after surgery. Hepatic function was evaluated by measuring serum bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase, and alanine aminotransferase (ALT) levels. The levels of malondialdehyde and the activity of superoxide dismutase, catalase, and GSH peroxidase (GSH-Px) were measured for assessment of oxidative stress. Liver morphology was analyzed by hematoxylin and eosin staining. EOHc normalized serum ALP, ALT, and bilirubin levels and inhibited morphological changes. In addition, we observed that EOHc inhibited elevation in hepatic lipid peroxidation and reduction of the glutathione peroxidase activity induced by sepsis. Our data show that EOHc plays a protective effect against liver injury induced by sepsis.
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KEYWORD
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essential oil, Hyptis crenata, liver dysfunction, medicinal plant, sepsis
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